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Anticholinergic Burden with Tricyclic Antidepressants: Cognitive and Cardiac Risks
25 November 2025 Miranda Fletley

Anticholinergic Burden with Tricyclic Antidepressants: Cognitive and Cardiac Risks

Tricyclic antidepressants like amitriptyline carry high anticholinergic burden, increasing risks of cognitive decline and dangerous heart rhythms. Safer alternatives exist, and many side effects are reversible with proper medication review.

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