Clindamycin Side Effects: What You Need to Know

If your doctor prescribed clindamycin, you probably have a good reason—it's great for skin infections, bone infections, and some dental issues. But like any antibiotic, it can bring unwanted reactions. Knowing what to expect helps you stay in control and avoid surprises.

Common side effects you’ll notice

The most frequent complaints are stomach‑related. You might feel nausea, a vague tummy ache, or a metallic taste that lingers after you swallow the pill. Diarrhea is also common; most people describe it as loose stools that come on within a few days of starting treatment.

These milder effects usually disappear once you finish the course. Drinking plenty of water, eating bland foods, and spacing the dose with meals can make them easier to handle. If the diarrhea is watery and you’re losing a lot of fluid, add an oral rehydration solution or a sports drink to keep electrolytes balanced.

When to seek help: serious reactions

Rare but critical reactions demand immediate attention. A sudden, severe diarrhea that’s watery, foul‑smelling, or contains blood could be a sign of Clostridioides difficile infection—a dangerous complication that needs a different antibiotic.

Allergic responses can range from a rash or itching to breathing trouble and swelling of the face or throat. If you notice hives, shortness of breath, or feel dizzy, call emergency services right away. Liver problems are uncommon but possible; watch for yellowing of the skin or eyes, dark urine, or persistent fatigue.

Other red‑flag symptoms include a rapid heartbeat, unexplained fever, or joint pain that doesn’t go away after a few days. When any of these appear, stop the medication and contact your healthcare provider.

Managing the milder side effects often means simple adjustments. Take clindamycin with food if an empty stomach upsets you. Probiotic foods like yogurt or a supplement can help keep good bacteria in balance and may reduce diarrhea risk.

Do not combine clindamycin with alcohol or other drugs that irritate the stomach unless your doctor says it’s safe. Certain over‑the‑counter antacids can change how well the drug is absorbed, so double‑check with a pharmacist.

Typical doses range from 150 mg to 600 mg every 6–8 hours, depending on the infection and your weight. Follow the prescription exactly—skipping doses can let the bacteria survive and become resistant.

Finish the full course even if you feel better. Stopping early may relieve symptoms, but it also gives any remaining germs a chance to bounce back, potentially leading to a more stubborn infection.

If you’re pregnant, nursing, or have liver disease, let your doctor know before starting clindamycin. The medication usually crosses the placenta in low amounts, but the benefits must outweigh any risk.

In summary, clindamycin is effective when used correctly, but it can cause a range of side effects—from mild nausea to serious intestinal infection. Keep an eye on how you feel, stay hydrated, and don’t hesitate to call your doctor if anything feels off. Being proactive means you get the infection cleared without unnecessary complications.